I-REJEON PCL Filler Injection Anti-wrinkle lifting and firming
Imvelaphi yeREJEON PCL
Kwiminyaka engama-20 edlulileyo, ukuqonda kwethu enye yezona ndawo zintsonkothileyo emzimbeni womntu - ubuso - kuye kwaphucuka ngokumangalisayo, kunye nezakhiwo ezininzi ze-anatomical ezichongiwe.
Ngelo xesha, i-plethora ye-non-utyando
sele zikhona iinkqubo zonyango
iimpawu zokuguga kunye nokubuyisela ulutsha
ukubonakala kobuso. I-REJEON ngowokuqala, kwaye
okwangoku ekuphela kwayo, i-collagen sti mulator eyenziwe nge-polycaprolactone microspheres, enegalelo kuphuculo lobuhle bayo oluhlala ixesha elide. REJEON
iimpawu ezizodwa zithetha ukuba lukhetho olunqwenelekayo kuluhlu lweenkqubo zezicubu ezithambileyo.
Isishwankathelo
Ukuqulunqwa kwe REJ EO N ,
7 0% esekelwe kwi-CMC yamanzi
ophethe ijelikwaye3 0 % PCL
ukwakheka,ivumela
isiphumo sokuzaliswa kwangoko
okubangelwa yiCMC, kulandelwa kukuvuselelwa kwecollagen yomzimba (neocollagenesis).
I-CMC ifakwe kwakhona kwi-2 ukuya ku-3
iinyanga emva kwesitofukwaye ngokuqhubekayo ithathelwa indawo yeyesigulana
icollagen (ubukhulu becala uhlobo I) luvuselelwe yi
PCL microspheres. Ii-microspheres ze-PCL nazo ziyakwazi ukufumaneka kwi-bioresorbable.
I-REJEON inenani leempawu ezenza ukuba ibe lukhetho olunomtsalane njenge-dermal filler:
①Ukufakwa kwe-polymer microspheres, malunga nenyanga ye-1, kunye ne-collagen scaffold ehambelanayo ikhusela ukusabela okungaphezulu kokuvuvukala ukuba kwenzeke13
②Uhlobo lwe-collagen oluhlala luhleli kwindawo etofweyo ubukhulu becala sisikafula se-collagen 'esikhulileyo' sohlobo lwe-collagen i-I5.
a) Ukunciphisa uhlobo lwe-collagen lwe-III luthetha ukuba akukho vuselelo olungakumbi lwempendulo yokuvuvukala
③Ukuthotywa kwe-REJEON kugqitywe nge-hydrolysis, kushiya nje amanzi kunye necarbon dioxide.
④Ngenxa yokuba umthamo wokugqibela kwindawo enyangweyo mkhulu kunomthamo we-Ellansé otofweyo, akukho mfuneko yokuba 'uchukumise' unyango.
a) Umthamo wokugqibela mkhulu kunomthamo ofakwe kwi-20-30% ngenxa yokwenziwa kohlobo lwe-collagen I-fibers11
⑤Ubukho beenguqulelo ezimbini ze-REJEON ezinexesha elahlukileyo lesenzo kuthetha ukuba ubude besiphumo sonyango sinokulungelelaniswa nesigulana.
iimfuno
a) Oku kuphunyezwa ngokutshintsha ubude bemixokelelwane ye-PCL, ukuvumela ukuqikelelwa, ukulawulwa kunye nokuhlengahlengiswa kwe-bioresorption.
⑥Indlela yonyango iyafana nokuba yeyiphi imveliso yeREJEON ekhethiweyo a) Kuyafana:
● Iimpawu zeRheological
● Ubuchule
● Isirinji
● Inaliti/cannula
I-REJEON PCL Ukwakheka okwahlukileyo
I-REJEON PCL yenziwe yinto eyodwa, enelungelo elilodwa lomenzi wechiza
NONE
● I-7 0% ye-carboxymethyl cellulose (CMC) - i-gel carrier carrier
● I-3 0% ye-polycaprolactone (PCL) i-microspheres (Umfanekiso 1.4) 3, 4, 5
Iimicrosphere zePCL zibanjelwe ngaphakathi
ukunqunyanyiswa homogeneous kwi-CMC-based gel carrier. I-PCL kunye ne-CMC zombini zineprofayili egqwesileyo kwaye eqinisekisiweyo ye-biocompatibility.
IREJEON PCL imathiriyeli eluhlaza ivela eGemany
I-PCL MICROSPHERES
I-PCL yipolyester yonyango engenatyhefu, eyaqala ukwenziwa ekuqaleni koo-1930s4, oko kukuthi.
ekhangayo ukuba isetyenziswe kwii-dermal fillers ngenxa yokulula kwayo i-bioresorption; ngokwemvelo ifakwe kwi-hydrolyzed kwi-carbon dioxide kunye namanzi ngaphakathi komzimba5.
Iimicrosphere zePCL ezisetyenziswa kwi
I-RE JEON yenzelwe ukunika
eyona biocompatibility6. Zinobuso obugudileyo, a
imilo engqukuva kunye nobukhulu be
malunga nama-25–50 μm
I-PCL ineprofayili egqwesileyo yokhuseleko3 kwaye isetyenziswe kwintsimi ye-biomedical iminyaka engaphezu kwe-70 kuluhlu lwezicelo, ukusuka kwi-sutures ukuya kwi-tissue kunye nokutshintshwa kwamalungu ngokuprintwa kwe-3D (Umfanekiso 1.6)4. Ikwasetyenziswa kwi-CE-ephawulwe kunye ne-US Food and
Ulawulo lweziyobisi (FDA)- iimveliso ezivunyiweyo.
IIPROPATI ZE-CMC
I-CMC yinto yendalo evela kwiselulosi; ayidityaniswanga, kwaye ayinayo ityhefu. Ezinye iipropati zayo ziquka (Umfanekiso 1.7)4 :
● Yinto eyaziwayo encedisa amayeza
● I-hygroscopic
● Ichongwe yi-FDA njengeyaziwa ngokubanzi njengekhuselekile ( GRAS)
● Ukubuyisela kwakhona kwenzeka kwiinyanga ezi-2 ukuya kwezi-3
Iingenelo eziphambili zeREJEON PCL Filler
I-REJEON PCL ine-microsphere ekhethekileyo kunye negqibeleleyo, kunye nobukhulu beengqungquthela ezihlangabezana nemigangatho yokhuseleko lwamazwe ngamazwe kunye nomgangatho ogudileyo onokuqhubeka nokukhuthaza ukukhula kwe-collagen.
Ukuvuselelwa kweCollagen nguREJEON: Ubungqina besayensi
REJEON uye waba
kuvavanywa kwisilwanyana
imodeli apho imivundla yatofwa ngayo
nokuba yiREJEON S
(PCL-1) okanye i-REJEON M (PCL-2) ukuphanda i-neocollagenesis5.
Kwiinyanga ezilithoba emva kokutofa kwe-PCL-1,
I-neocollagenesis yenzekile kwaye i-PCL microspheres ye-PCL-1 yayihlaziywe ngokupheleleyo (Umfanekiso 1. 1 1) 5.
Okwangoku, nge-PCL-2 kwiinyanga ze-9,
bekukho ubungqina bokusekwa kwe
uhlobo I kwaye uchwetheze III collagen ngeenxa zonke
PCL microspheres. Kwiinyanga ze-2 ze-post-injection, i-PCL-2 i-microspheres yayisekho kwi-tissue injected5.
Kuphononongo olulingwayo lwe-RE JEO N ebantwini, izigulana zabhaliswa ukuba zifumane i-Ellansé etofelwe nge-intradermally etempileni.
ummandla9. Uhlalutyo lwe-Histological lwezicubu ezifunyenwe kwii-biopsies zityhiliwe
ukubunjwa kwe-collagen malunga neengqungquthela ze-PCL ezijojowe (Umfanekiso 1. 12) 9, ukuxhasa iziphumo ezifanayo eziboniswe ngaphambili
izicubu zomvundla5.
REJEON indlela yokusebenza
I-REJEON inezigaba ezibini ezahlukeneyo zomsebenzi (Umfanekiso 1.9)1,4 :
● Inyathelo loku-1: Ngokukhawuleza emva kokutofa, icandelo le-CMC libonelela ngevolumu yethutyana,
ethi iyancipha ngokuthe ngcembe kwiinyanga ezi-2-3
● Inyathelo lesi-2: I-PCL microspheres induce
I-neocollagenesis yeentlobo ze-I kunye ne-III collagen, kunye nohlobo oluqhubekayo oluqhubekayo lwe-collagen
Ulwakhiwo lwanda ngokuthe ngcembe kwiinyanga ezi-1 ukuya kwezi-3 kunye ne-PCL microspheres
ukuba ifakwe kuhlobo lwe-collagen
isikafula. Isiphumo somthamo we-collagen
ithatha indawo yokunyuka kwevolumu yokuqala okubangelwa yijeli yeCMC
I-collagen scaffold ekhuthazwa yi-PCL
iimicrospheres ziyaqhubeka emva kokuba ziphinde zafakwa, okukhokelela ekonyusweni kwevolumu ehlala ixesha elide ebonwa ngeREJEON.
I-REJEON PCL Filler ineziphumo ezilungileyo
I-REJEON PCL Filler yi-ejenti yokuzalisa ehlala ixesha elide enokuthi igudise umkhondo oshiywe lixesha kwaye ibuyisele imbonakalo yobutsha kunye neyobutsha ebusweni.
IREJEON PCL FILLER IMPENDULO YOMTHENGI
Sizimisele ukwabelana ngobuchule bethu kunye
ulwazi xa kunye nendlela yokudibanisa i-r ej eon ekusebenzeni kweklinikhi. Ndiyathemba ukuba iyakunceda umfundi ngendlela enye endisebenzele ngayo kule minyaka ili-10 idlulileyo: ukunika unyango olukhuselekileyo oluneziphumo ezingcono kunye neziphumo ezihlala ixesha elide. I-RE JEON sisixhobo esisisiseko ekusebenzeni kwam kwaye indenze i-injector engcono! ”
UGqr Francisco de Melo
UGqirha wePlastiki, e-UAE
“ IRE JEON ibiyeyona nto ndiyithandayo yokugcwalisa idermal
Iminyaka eyi-7. Le ncwadi iza kukunceda ukwazi ukuyisebenzisa kakuhle
RE JEON kwaye uya kuyithanda. ”
UGqr Shang- Lin
Ugqirha wesikhumba, eTaiwan
“Ukuphuculwa kolwakhiwo kunye nolusu
umgangatho ophuma kwi RE JOE N 's unique
I-neocollagenesis ayifani. Ngokungathandabuzekiyo esinye sezona zixhobo zingcono kwiiklinikhi ezifuna ukusebenza kakuhle kunye nokhuseleko kwimveliso etofwayo. I-REJ EO N ine
amandla okubonelela ngokuphakamisa okuhlala ixesha elide kunye nokwakhiwa kobuso okwandisiweyo ngeseshoni enye nje. ”
UGqr Ingrid Ló pez- Gehrke
Ugqirha wesikhumba, eMexico
“Ndifumana uyolo olukhulu ekusebenziseni iRE JEON ngenxa yesiphumo sayo sokucula sevol umi. Oku kuvumela ngaphantsi
imveliso eza kusetyenziswa, kwaye ngemveliso yokwenyani yohlobo lwe-collagen I, inomthamo wokwenyani wesikhumba
ukuzalwa ngokutsha. Izigulana ezininzi zithi kum: ‘Siyaqala ngqa
Ndinento ehlala ihleli', okanye 'Jonga umgangatho wolusu lwam'. Ngokuqinisekileyo ifayile yam endiyithandayo. ”
UGqr Pierre Nicolau
UGqirha wePlastiki, eSpain
REJEON IIMBALASANA EZINGUNDOQO
Ukulandela uphando olubanzi kunye nophuhliso, kunye neklinikhi
uvavanyo, iREJEON ifumene isatifikethi se-ISO 13485 yeNkqubo yoLawulo loMgangatho kwi
20081 (Umfanekiso 1.2). Ngo-2009, ukuvunywa kwamanqaku e-European Conformity (CE) kwaba
kunikwe, ukukhokela
kuphehlelelo olunempumelelo kakhulu lwe
imveliso e-UK, eJamani naseSpain. Kwalandela okunye ukuqaliswa, ngokubhaliswa ngaphezulu kwama-69
amazwe ngo 2018. Nge 2019, i
Isikhumbuzo seminyaka eyi-10 sokulahlwa, ngaphezulu
iisirinji ezingaphezulu kwesigidi ezithengisiweyo
kwihlabathi jikelele. Kodwa ibali lempumelelo alizange liphelele apho, kunye nesiza esitsha sokwenza eNetherlands siqala
imveliso ngo-2020
REJEON PCL PRODUCT Iinkcukacha
1ml/iqhekeza
Yamkela ukupakishwa okulungiselelwe kwe-OEM
